From all the home-based business ideas on our website, this one is the easiest to start AND most profitable, too. If you have an extra room in your home which is not being used, why not turn it into a money-maker by renting it out on a nightly basis? Depending on where you are located, you could charge anywhere from $40 - $80 per night. If your home is located in a highly populated city which attracts a lot of tourists, you could easily charge over $100/night. To get started, go to AirBnB's website and register. Don't forget to take nice photos of the room you're promoting!